2016FallSymposiumURCreativityEngagement has ended
Tuesday, December 6 • 8:40am - 9:00am
Investigation of Pregnancy Categories and GABAA Receptor Interactions of Common General Anesthetics

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This literature based research project investigates the chemical structure of three anesthetic agents and compares them to their given pregnancy category.  Pregnancy categories give the administering physician an idea as to whether the drug will affect the in-utero patient.  Sodium thiopental, a barbiturate, has been used in the medical field since 1934, and it is categorized as a pregnancy category C.  Midazolam is a benzodiazepine derivative; its use began in the 1980’s and it is classified as a category D drug.  Propofol, a category B agent, is unrelated to all other anesthetic agents, its use began in the United Kingdom and New Zealand in 1986.  The three anesthetics of interest have advantages and disadvantages, thiopental and propofol being similar.  Controversy surrounds the claim midazolam causes hypotonia also known as “floppy baby syndrome.”  The anesthetic agents of interest pharmacologically effect the gamma amino butyric acid A receptor (GABAAR), but their effects differ due to the locations of their binding sites.     This research is important because very little is understood about maternal and in-utero physiology, pharmacodynamics and pharmacokinetics of anesthetic agent within the pregnant woman and fetus, as well as the exact interactions that occur between the anesthetic and the central nervous system. 


Tuesday December 6, 2016 8:40am - 9:00am
014 Zeis Hall