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2016FallSymposiumURCreativityEngagement has ended
Tuesday, December 6 • 12:40pm - 1:20pm
The stability of Glucuronidated Phthalate Metabolites at Various pH’s

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Phthalates, found in many household products, have been shown to have a significant impact on human health. In particular, phthalates have been shown to be disruptive to the hormone testosterone. Disruption of testosterone during pregnancy is known to cause a variety of birth defects in male infants including: decreased anogenital distance, as well as, size and function of male reproductive organs. We hypothesize human variability factors, such as, gender, race, smoking status, and age lead to differential risk from phthalate exposure. We seek to understand the effect of varying pH values on the stability of phthalate metabolites in human urine, which can range from 4.5-8.0. This knowledge will improve our understanding of the stability of these compounds. We will also acquire an understanding of the extent to which phthalates may be studied to gain insight into the variation of human susceptibility. The urine samples were analyzed after thawing and then again after altercation of pH and temperature. Urine samples were purified through solid phase extraction and by high performance liquid chromatography. Samples were analyzed with atmospheric pressure chemical ionization tandem mass spectrometry.

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Tuesday December 6, 2016 12:40pm - 1:20pm
014 Zeis Hall